![]() ![]() Although they will ultimately be spread out by the formation of bone tissue, early osteoblasts appear in a cluster called an ossification center. Some of these cells will differentiate into capillaries, while others will become osteogenic cells and then osteoblasts. The process begins when mesenchymal cells in the embryonic skeleton gather together and begin to differentiate into specialized cells ( Figure 6.4.1 a). The flat bones of the face, most of the cranial bones, and the clavicles (collarbones) are formed via intramembranous ossification. Intramembranous Ossificationĭuring intramembranous ossification, compact and spongy bone develops directly from sheets of mesenchymal (undifferentiated) connective tissue. There are two osteogenic pathways-intramembranous ossification and endochondral ossification-but in the end, mature bone is the same regardless of the pathway that produces it. By the sixth or seventh week of embryonic life, the actual process of bone development, ossification (osteogenesis), begins. In the early stages of embryonic development, the embryo’s skeleton consists of fibrous membranes and hyaline cartilage. Compare and contrast the interstitial and appositional growth.Compare and contrast the processes of intramembranous and endochondral bone formation.Explain the growth activity at the epiphyseal plate.List the steps of endochondral ossification.Explain the role of cartilage in bone formation.List the steps of intramembranous ossification. ![]() By the end of this section, you will be able to:ĭiscuss the process of bone formation and development. ![]()
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